The epidermal growth factor receptor variant type III mutation frequently found in gliomas induces astrogenesis in human cerebral organoids

OBJECTIVES: The epidermal growth factor receptor variant type III (EGFRvIII) is the most common mutation of EGFR in glioblastoma multiforme (GBM) and is found in approximately 25% of all GBMs. Intriguingly, EGFRvIII is mostly found in GFAP(+) astrocytic tumour cells in the brain, suggesting connecti...

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Detalles Bibliográficos
Autores principales: Kim, Hyun‐Mun, Lee, Sang‐Hyeok, Lim, Jaejoon, Yoo, Jongman, Hwang, Dong‐Youn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7848959/
https://www.ncbi.nlm.nih.gov/pubmed/33283409
http://dx.doi.org/10.1111/cpr.12965

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7848959/
https://www.ncbi.nlm.nih.gov/pubmed/33283409
http://dx.doi.org/10.1111/cpr.12965

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