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Phenotyping Study of Cyclophosphamide 4-Hydroxylation in Malay Cancer Patients
BACKGROUND: Cyclophosphamide (CP) is an anticancer alkylating group (nitrogen mustard) and a prodrug that will be metabolized to form its active metabolite, 4-hydroxycyclophosphamide (4-OHCP). The various enzymes involved in its bioactivation can cause a wide range of CP expression and activity amon...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Dove
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7849187/ https://www.ncbi.nlm.nih.gov/pubmed/33536743 http://dx.doi.org/10.2147/DDDT.S279128 |