Novel library synthesis of 3,4-disubstituted pyridin-2(1H)-ones via cleavage of pyridine-2-oxy-7-azabenzotriazole ethers under ionic hydrogenation conditions at room temperature

In our hands, efficient access to the 4-amino-3-carboxamide disubstituted pyridine-2(1H)-one kinase hinge-binder motif proved to be more challenging than anticipated requiring a significant investment in route scouting and optimization. This full paper focuses on the synthesis issues that we encount...

Descripción completa

Detalles Bibliográficos
Autores principales: Pierre, Romain, Brethon, Anne, Jacques, Sylvain A, Blond, Aurélie, Chambon, Sandrine, Talano, Sandrine, Raffin, Catherine, Musicki, Branislav, Bouix-Peter, Claire, Tomas, Loic, Ouvry, Gilles, Morgentin, Rémy, Hennequin, Laurent F, Harris, Craig S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2021
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7849264/
https://www.ncbi.nlm.nih.gov/pubmed/33564326
http://dx.doi.org/10.3762/bjoc.17.16

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7849264/
https://www.ncbi.nlm.nih.gov/pubmed/33564326
http://dx.doi.org/10.3762/bjoc.17.16

Ejemplares similares