Topoisomerase I prevents transcription-replication conflicts at transcription termination sites

R-loops have both positive and negative impacts on chromosome functions. To identify toxic R-loops, we mapped RNA:DNA hybrids, markers of replication fork stalling and DNA double-strand breaks along the human genome. This analysis indicates that transient replication fork pausing occurs at the trans...

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Detalles Bibliográficos
Autores principales: Liu, Yaqun, Lin, Yea-Lih, Pasero, Philippe, Chen, Chun-Long
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7849740/
https://www.ncbi.nlm.nih.gov/pubmed/33553603
http://dx.doi.org/10.1080/23723556.2020.1843951

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7849740/
https://www.ncbi.nlm.nih.gov/pubmed/33553603
http://dx.doi.org/10.1080/23723556.2020.1843951

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