Ataxia-telangiectasia mutated interacts with Parkin and induces mitophagy independent of kinase activity. Evidence from mantle cell lymphoma

Ataxia telangiectasia mutated (ATM), a critical DNA damage sensor with protein kinase activity, is frequently altered in human cancers including mantle cell lymphoma. Loss of ATM protein is linked to accumulation of nonfunctional mitochondria and defective mitophagy in both murine thymocytes and in...

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Detalles Bibliográficos
Autores principales: Sarkar, Aloke, Stellrecht, Christine M., Vangapandu, Hima V., Ayres, Mary, Kaipparettu, Benny A., Park, Jun Hyoung, Balakrishnan, Kumudha, Burks, Jared K., Pandita, Tej K., Hittelman, Walter N., Neelapu, Sattva S., Gandhi, Varsha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Fondazione Ferrata Storti 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7849759/
https://www.ncbi.nlm.nih.gov/pubmed/32029507
http://dx.doi.org/10.3324/haematol.2019.234385

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7849759/
https://www.ncbi.nlm.nih.gov/pubmed/32029507
http://dx.doi.org/10.3324/haematol.2019.234385

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