Common light chain chickens produce human antibodies of high affinity and broad epitope coverage for the engineering of bispecifics

Bispecific antibodies are an important and growing segment in antibody therapeutics, particularly in the immuno-oncology space. Manufacturing of a bispecific antibody with two different heavy chains is greatly simplified if the light chains can be the same for both arms of the antibody. Here, we int...

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Detalles Bibliográficos
Autores principales: Ching, Kathryn H., Berg, Kimberley, Reynolds, Kevin, Pedersen, Darlene, Macias, Alba, Abdiche, Yasmina N., Harriman, William D., Leighton, Philip A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7849766/
https://www.ncbi.nlm.nih.gov/pubmed/33491549
http://dx.doi.org/10.1080/19420862.2020.1862451

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7849766/
https://www.ncbi.nlm.nih.gov/pubmed/33491549
http://dx.doi.org/10.1080/19420862.2020.1862451

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