Spironolactone-induced XPB degradation requires TFIIH integrity and ubiquitin-selective segregase VCP/p97

Mineralocorticoid and androgen receptor antagonist, spironolactone, was recently identified as an inhibitor of nucleotide excision repair (NER), acting via induction of proteolysis of TFIIH component Xeroderma Pigmentosum B protein (XPB). This activity provides a strong rationale for repurposing spi...

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Detalles Bibliográficos
Autores principales: Chauhan, Anil K., Li, Ping, Sun, Yingming, Wani, Gulzar, Zhu, Qianzheng, Wani, Altaf A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7849777/
https://www.ncbi.nlm.nih.gov/pubmed/33381997
http://dx.doi.org/10.1080/15384101.2020.1860559

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7849777/
https://www.ncbi.nlm.nih.gov/pubmed/33381997
http://dx.doi.org/10.1080/15384101.2020.1860559

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