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Spironolactone-induced XPB degradation requires TFIIH integrity and ubiquitin-selective segregase VCP/p97
Mineralocorticoid and androgen receptor antagonist, spironolactone, was recently identified as an inhibitor of nucleotide excision repair (NER), acting via induction of proteolysis of TFIIH component Xeroderma Pigmentosum B protein (XPB). This activity provides a strong rationale for repurposing spi...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7849777/ https://www.ncbi.nlm.nih.gov/pubmed/33381997 http://dx.doi.org/10.1080/15384101.2020.1860559 |