Cargando…

Inhibition of aerobic glycolysis alleviates sepsis-induced acute kidney injury by promoting lactate/Sirtuin 3/AMPK-regulated autophagy

Metabolism reprogramming influences the severity of organ dysfunction, progression to fibrosis, and development of disease in acute kidney injury (AKI). Previously we showed that inhibition of aerobic glycolysis improved survival rates and protected septic mice from kidney injury. However, the under...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tan, Chuyi, Gu, Jia, Li, Tao, Chen, Huan, Liu, Ke, Liu, Meidong, Zhang, Huali, Xiao, Xianzhong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2021
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7849980/ https://www.ncbi.nlm.nih.gov/pubmed/33448325 http://dx.doi.org/10.3892/ijmm.2021.4852

Ejemplares similares

Pentraxin-3 Is a Strong Biomarker of Sepsis Severity Identification and Predictor of 90-Day Mortality in Intensive Care Units via Sepsis 3.0 Definitions
por: Chen, Huan, et al.
Publicado: (2021)

Sinomenine Hydrochloride Protects against Polymicrobial Sepsis via Autophagy
por: Jiang, Yu, et al.
Publicado: (2015)

Identification of pathogen(s) in infectious diseases using shotgun metagenomic sequencing and conventional culture: a comparative study
por: Chen, Huan, et al.
Publicado: (2021)

Resveratrol protects against early polymicrobial sepsis-induced acute kidney injury through inhibiting endoplasmic reticulum stress-activated NF-κB pathway
por: Wang, Nian, et al.
Publicado: (2017)

Aerobic glycolysis and high level of lactate in cancer metabolism and microenvironment
por: Jiang, Bo
Publicado: (2017)

Lactate as an Astroglial Signal Augmenting Aerobic Glycolysis and Lipid Metabolism
por: Horvat, Anemari, et al.
Publicado: (2021)

HSF1 Attenuates LPS-Induced Acute Lung Injury in Mice by Suppressing Macrophage Infiltration
por: Li, Tao, et al.
Publicado: (2020)

DOCK8 inhibits the immune function of neutrophils in sepsis by regulating aerobic glycolysis
por: Zhu, Hongjun, et al.
Publicado: (2023)

WSSV exploits AMPK to activate mTORC2 signaling for proliferation by enhancing aerobic glycolysis
por: Zhang, Peng, et al.
Publicado: (2023)

Enhancement of Astroglial Aerobic Glycolysis by Extracellular Lactate-Mediated Increase in cAMP
por: Vardjan, Nina, et al.
Publicado: (2018)

Water-Extracted Prunella vulgaris Alleviates Endometriosis by Reducing Aerobic Glycolysis
por: Cho, Min Kyoung, et al.
Publicado: (2022)

Lactate is a bridge linking glycolysis and autophagy through lactylation
por: Sun, Weixia, et al.
Publicado: (2023)

Zinc finger E-box-binding homeobox 1 mediates aerobic glycolysis via suppression of sirtuin 3 in pancreatic cancer
por: Xu, Wen-Yan, et al.
Publicado: (2018)

Activation of sirtuin 1/3 improves vascular hyporeactivity in severe hemorrhagic shock by alleviation of mitochondrial damage
por: Li, Pengyun, et al.
Publicado: (2015)

AMPK Inhibition Suppresses the Malignant Phenotype of Pancreatic Cancer Cells in Part by Attenuating Aerobic Glycolysis
por: Hu, Mingyue, et al.
Publicado: (2019)

Aggravation of acute kidney injury by mPGES-2 down regulation is associated with autophagy inhibition and enhanced apoptosis
por: Li, Ting, et al.
Publicado: (2017)

Corrigendum: Water-extracted Prunella vulgaris alleviates endometriosis by reducing aerobic glycolysis
por: Cho, Min Kyoung, et al.
Publicado: (2022)

Lactate dehydrogenase A negatively regulated by miRNAs promotes aerobic glycolysis and is increased in colorectal cancer
por: Wang, Jian, et al.
Publicado: (2015)

Author Correction: Aggravation of acute kidney injury by mPGES-2 down regulation is associated with autophagy inhibition and enhanced apoptosis
por: Li, Ting, et al.
Publicado: (2018)

Suppression of sirtuin 1 alleviates airway inflammation through mTOR-mediated autophagy
por: Wu, Yuanyuan, et al.
Publicado: (2020)

LINC01605 promotes aerobic glycolysis through lactate dehydrogenase A in triple‐negative breast cancer
por: Wang, Wei, et al.
Publicado: (2022)

Ginsenoside Rg3 attenuates sepsis-induced injury and mitochondrial dysfunction in liver via AMPK-mediated autophagy flux
por: Xing, Wei, et al.
Publicado: (2017)

Quinoline 3-sulfonamides inhibit lactate dehydrogenase A and reverse aerobic glycolysis in cancer cells
por: Billiard, Julia, et al.
Publicado: (2013)

PACAP–Sirtuin3 alleviates cognitive impairment through autophagy in Alzheimer’s disease
por: Wang, Qing, et al.
Publicado: (2023)

SDHB downregulation facilitates the proliferation and invasion of colorectal cancer through AMPK functions excluding those involved in the modulation of aerobic glycolysis
por: Xiao, Zhiming, et al.
Publicado: (2018)

N-acetylcysteine alleviates H(2)O(2)-induced damage via regulating the redox status of intracellular antioxidants in H9c2 cells
por: Liu, Xiehong, et al.
Publicado: (2019)

Aerobic Glycolysis: Beyond Proliferation
por: Jones, William, et al.
Publicado: (2015)

Lifelong Aerobic Exercise Alleviates Sarcopenia by Activating Autophagy and Inhibiting Protein Degradation via the AMPK/PGC-1α Signaling Pathway
por: Liang, Jiling, et al.
Publicado: (2021)

Chaperone-mediated autophagy promotes breast cancer angiogenesis via regulation of aerobic glycolysis
por: Chen, Rui, et al.
Publicado: (2023)

Sirtuins and Immuno-Metabolism of Sepsis
por: Wang, Xianfeng, et al.
Publicado: (2018)

Glycolysis maintains AMPK activation in sorafenib-induced Warburg effect
por: Guo, Sijia, et al.
Publicado: (2023)

α-Mangostin Alleviated HIF-1α-Mediated Angiogenesis in Rats With Adjuvant-Induced Arthritis by Suppressing Aerobic Glycolysis
por: Jiang, Tian-Tian, et al.
Publicado: (2021)

Aerobic glycolysis, motility, and cytoskeletal remodeling
por: Verdone, James E, et al.
Publicado: (2015)

WWOX loss activates aerobic glycolysis
por: Abu-Remaileh, Muhannad, et al.
Publicado: (2014)

Proton export upregulates aerobic glycolysis
por: Russell, Shonagh, et al.
Publicado: (2022)

Resveratrol protects against L-arginine-induced acute necrotizing pancreatitis in mice by enhancing SIRT1-mediated deacetylation of p53 and heat shock factor 1
por: Wang, Nian, et al.
Publicado: (2017)

Catabolic efficiency of aerobic glycolysis: The Warburg effect revisited
por: Vazquez, Alexei, et al.
Publicado: (2010)

A novel AMPK activator shows therapeutic potential in hepatocellular carcinoma by suppressing HIF1α‐mediated aerobic glycolysis
por: Tseng, Hsing‐I, et al.
Publicado: (2022)

ZNF667/Mipu1 Is a Novel Anti-Apoptotic Factor That Directly Regulates the Expression of the Rat Bax Gene in H9c2 Cells
por: Jiang, Lei, et al.
Publicado: (2014)

RRP Regulates Autophagy through the AMPK Pathway to Alleviate the Effect of Cell Senescence on Atherosclerosis
por: Liu, Dekun, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_0mf61u53ckeudphsfvtu59pvn0