Challenges and opportunities to develop enediyne natural products as payloads for antibody-drug conjugates

Calicheamicin, the payload of the antibody-drug-conjugates (ADCs) gemtuzumab ozogamicin (Mylotarg®) and inotuzumab ozogamicin (Besponsa®), belongs to the class of enediyne natural products. Since the isolation and structural determination of the neocarzinostatin chromophore in 1985, the enediynes ha...

Descripción completa

Detalles Bibliográficos
Autores principales: Adhikari, Ajeeth, Shen, Ben, Rader, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7850032/
https://www.ncbi.nlm.nih.gov/pubmed/33554043
http://dx.doi.org/10.1093/abt/tbab001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7850032/
https://www.ncbi.nlm.nih.gov/pubmed/33554043
http://dx.doi.org/10.1093/abt/tbab001

Ejemplares similares