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Challenges and opportunities to develop enediyne natural products as payloads for antibody-drug conjugates

Calicheamicin, the payload of the antibody-drug-conjugates (ADCs) gemtuzumab ozogamicin (Mylotarg®) and inotuzumab ozogamicin (Besponsa®), belongs to the class of enediyne natural products. Since the isolation and structural determination of the neocarzinostatin chromophore in 1985, the enediynes ha...

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Detalles Bibliográficos
Autores principales:	Adhikari, Ajeeth, Shen, Ben, Rader, Christoph
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7850032/ https://www.ncbi.nlm.nih.gov/pubmed/33554043 http://dx.doi.org/10.1093/abt/tbab001

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