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An information-theoretic approach for measuring the distance of organ tissue samples using their transcriptomic signatures

MOTIVATION: Recapitulating aspects of human organ functions using in vitro (e.g. plates, transwells, etc.), in vivo (e.g. mouse, rat, etc.), or ex vivo (e.g. organ chips, 3D systems, etc.) organ models is of paramount importance for drug discovery and precision medicine. It will allow us to identify...

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Detalles Bibliográficos
Autores principales: Manatakis, Dimitris V, VanDevender, Aaron, Manolakos, Elias S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7850114/
https://www.ncbi.nlm.nih.gov/pubmed/32683449
http://dx.doi.org/10.1093/bioinformatics/btaa654