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Inefficiencies in phase II to phase III transition impeding successful drug development in glioblastoma
BACKGROUND: Improving outcomes of patients with glioblastoma (GBM) represents a significant challenge in neuro-oncology. We undertook a systematic review of key parameters of phase II and III trials in GBM to identify and quantify the impact of trial design on this phenomenon. METHODS: Studies betwe...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7850118/ https://www.ncbi.nlm.nih.gov/pubmed/33543145 http://dx.doi.org/10.1093/noajnl/vdaa171 |