Pharmacokinetics and Toxicities of Oral Docetaxel Formulations Co-Administered with Ritonavir in Phase I Trials

INTRODUCTION: Docetaxel is widely used as intravenous (IV) chemotherapy. Oral docetaxel is co-administered with the cytochrome P450 3A4 and P-glycoprotein inhibitor ritonavir to increase oral bioavailability. This research explores the relationship between the pharmacokinetics (PK) and toxicity of t...

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Detalles Bibliográficos
Autores principales: Vermunt, Marit, Marchetti, Serena, Beijnen, Jos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7850405/
https://www.ncbi.nlm.nih.gov/pubmed/33536797
http://dx.doi.org/10.2147/CPAA.S292746

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7850405/
https://www.ncbi.nlm.nih.gov/pubmed/33536797
http://dx.doi.org/10.2147/CPAA.S292746

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