Induced neural stem cells from human patient-derived fibroblasts attenuate neurodegeneration in Niemann-Pick type C mice

BACKGROUND: Niemann-Pick disease type C (NPC) is caused by the mutation of NPC genes, which leads to the abnormal accumulation of unesterified cholesterol and glycolipids in lysosomes. This autosomal recessive disease is characterized by liver dysfunction, hepatosplenomegaly, and progressive neurode...

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Detalles Bibliográficos
Autores principales: Hong, Saetbyul, Lee, Seung-Eun, Kang, Insung, Yang, Jehoon, Kim, Hunnyun, Kim, Jeyun, Kang, Kyung-Sun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Veterinary Science 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7850792/
https://www.ncbi.nlm.nih.gov/pubmed/33522159
http://dx.doi.org/10.4142/jvs.2021.22.e7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7850792/
https://www.ncbi.nlm.nih.gov/pubmed/33522159
http://dx.doi.org/10.4142/jvs.2021.22.e7

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