Activator-Mediated Pyruvate Kinase M2 Activation Contributes to Endotoxin Tolerance by Promoting Mitochondrial Biogenesis

Pyruvate kinase M2 (PKM2) is a key glycolysis enzyme, and its effect on macrophages has not been entirely elucidated. Here, we identified that the PKM2 small-molecule agonist TEPP-46 mediated PKM2 activation by inducing the formation of PKM2 tetramer and promoted macrophage endotoxin tolerance. Lipo...

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Detalles Bibliográficos
Autores principales: Yi, Zhujun, Wu, Yilin, Zhang, Wenfeng, Wang, Tao, Gong, Jianping, Cheng, Yao, Miao, Chunmu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7851049/
https://www.ncbi.nlm.nih.gov/pubmed/33542713
http://dx.doi.org/10.3389/fimmu.2020.595316

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7851049/
https://www.ncbi.nlm.nih.gov/pubmed/33542713
http://dx.doi.org/10.3389/fimmu.2020.595316

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