Hepatitis C virus core protein activates proteasomal activator 28 gamma to downregulate p16 levels via ubiquitin-independent proteasomal degradation

Proteasomal activator 28 gamma (PA28γ), an essential constituent of the 20S proteasome, is frequently overexpressed in hepatocellular carcinoma. Hepatitis C virus (HCV) core protein is recently known to activate PA28γ expression in human hepatocytes via upregulation of p53 levels; however, its role...

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Detalles Bibliográficos
Autores principales: Cha, Sungkyung, Park, Inbeom, Jang, Kyung Lib
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7851347/
https://www.ncbi.nlm.nih.gov/pubmed/33553768
http://dx.doi.org/10.1016/j.heliyon.2021.e06134

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7851347/
https://www.ncbi.nlm.nih.gov/pubmed/33553768
http://dx.doi.org/10.1016/j.heliyon.2021.e06134

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