APC loss induces Warburg effect via increased PKM2 transcription in colorectal cancer

BACKGROUND: Most cancer cells employ the Warburg effect to support anabolic growth and tumorigenesis. Here, we discovered a key link between Warburg effect and aberrantly activated Wnt/β-catenin signalling, especially by pathologically significant APC loss, in CRC. METHODS: Proteomic analyses were p...

Descripción completa

Detalles Bibliográficos
Autores principales: Cha, Pu-Hyeon, Hwang, Jeong-Ha, Kwak, Dong-Kyu, Koh, Eunjin, Kim, Kyung-Sup, Choi, Kang-Yell
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7851388/
https://www.ncbi.nlm.nih.gov/pubmed/33071283
http://dx.doi.org/10.1038/s41416-020-01118-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7851388/
https://www.ncbi.nlm.nih.gov/pubmed/33071283
http://dx.doi.org/10.1038/s41416-020-01118-7

Ejemplares similares