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APC loss induces Warburg effect via increased PKM2 transcription in colorectal cancer
BACKGROUND: Most cancer cells employ the Warburg effect to support anabolic growth and tumorigenesis. Here, we discovered a key link between Warburg effect and aberrantly activated Wnt/β-catenin signalling, especially by pathologically significant APC loss, in CRC. METHODS: Proteomic analyses were p...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7851388/ https://www.ncbi.nlm.nih.gov/pubmed/33071283 http://dx.doi.org/10.1038/s41416-020-01118-7 |