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Synthesis, in silico ADME, molecular docking and in vitro cytotoxicity evaluation of stilbene linked 1,2,3-triazoles

Series of (E)-1-benzyl-4-((4-styrylphenoxy)methyl)-1H-1,2,3-triazoles 7a-x were obtained by Wittig reaction between 4-((1-benzyl-1H-1,2,3-triazol-4-yl)methoxy)benzaldehydes 5a-d and benzyl triphenylphosphonium halides 6a-f in benzene. The structures of the synthesized compounds were confirmed by FTI...

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Detalles Bibliográficos
Autores principales: Das, Arnika, Kumar, Sujeet, Persoons, Leentje, Daelemans, Dirk, Schols, Dominique, Alici, Hakan, Tahtaci, Hakan, Karki, Subhas S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7851791/
https://www.ncbi.nlm.nih.gov/pubmed/33553718
http://dx.doi.org/10.1016/j.heliyon.2020.e05893