Cargando…

The prion-like domain of Fused in Sarcoma is phosphorylated by multiple kinases affecting liquid- and solid-phase transitions

Fused in Sarcoma (FUS) is a ubiquitously expressed protein that can phase-separate from nucleoplasm and cytoplasm into distinct liquid-droplet structures. It is predominantly nuclear and most of its functions are related to RNA and DNA metabolism. Excessive persistence of FUS within cytoplasmic phas...

Descripción completa

Detalles Bibliográficos
Autores principales:	Owen, Izzy, Rhoads, Shannon, Yee, Debra, Wyne, Hala, Gery, Kevin, Hannula, Isabelle, Sundrum, Meenakshi, Shewmaker, Frank
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2020
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7851872/ https://www.ncbi.nlm.nih.gov/pubmed/32877292 http://dx.doi.org/10.1091/mbc.E20-05-0290

Ejemplares similares

The Role of Post-Translational Modifications on Prion-Like Aggregation and Liquid-Phase Separation of FUS
por: Rhoads, Shannon N., et al.
Publicado: (2018)

Yeast Models of Prion-Like Proteins That Cause Amyotrophic Lateral Sclerosis Reveal Pathogenic Mechanisms
por: Monahan, Zachary T., et al.
Publicado: (2018)

The Role of Post-Translational Modifications in the Phase Transitions of Intrinsically Disordered Proteins
por: Owen, Izzy, et al.
Publicado: (2019)

25 years of yeast prions: Symposium honouring the 25-year anniversary of Reed Wickner’s discovery of yeast prions
por: Shewmaker, Frank, et al.
Publicado: (2020)

Prion variants, species barriers, generation and propagation
por: Wickner, Reed B, et al.
Publicado: (2009)

Casein kinase 1δ/ε phosphorylates fused in sarcoma (FUS) and ameliorates FUS-mediated neurodegeneration
por: Kishino, Yuya, et al.
Publicado: (2022)

The prionlike domain of FUS is multiphosphorylated following DNA damage without altering nuclear localization
por: Rhoads, Shannon N., et al.
Publicado: (2018)

Effects of Mass Change on Liquid–Liquid Phase Separation of the RNA-Binding Protein Fused in Sarcoma
por: Dong, Weiqian, et al.
Publicado: (2023)

Fused in sarcoma regulates DNA replication timing and kinetics
por: Jia, Weiyan, et al.
Publicado: (2021)

Proximity-based labeling reveals DNA damage–induced phosphorylation of fused in sarcoma (FUS) causes distinct changes in the FUS protein interactome
por: Johnson, Michelle A., et al.
Publicado: (2022)

Behavior of Prions in the Environment: Implications for Prion Biology
por: Bartelt-Hunt, Shannon L., et al.
Publicado: (2013)

Phosphorylation of the FUS low‐complexity domain disrupts phase separation, aggregation, and toxicity
por: Monahan, Zachary, et al.
Publicado: (2017)

Fused in Sarcoma: Properties, Self-Assembly and Correlation with Neurodegenerative Diseases
por: Chen, Chen, et al.
Publicado: (2019)

Phenotype Analysis of Fused in Sarcoma Mutations in Amyotrophic Lateral Sclerosis
por: Grassano, Maurizio, et al.
Publicado: (2022)

Fused in sarcoma undergoes cold denaturation: Implications for phase separation
por: Félix, Sara S., et al.
Publicado: (2023)

Autophagy dysregulation by mutant fused in sarcoma—implications for amyotrophic lateral sclerosis
por: Soo, K Y, et al.
Publicado: (2015)

Conformational Fluctuations and Phases in Fused in Sarcoma (FUS) Low-Complexity Domain
por: Thirumalai, D., et al.
Publicado: (2023)

Targeting Prion-like Cis Phosphorylated Tau Pathology in Neurodegenerative Diseases
por: Albayram, Onder, et al.
Publicado: (2018)

Development of Alkaline Phosphatase-Fused Mouse Prion Protein and Its Application in Toxic Aβ Oligomer Detection
por: Tsukakoshi, Kaori, et al.
Publicado: (2022)

Material Considerations for Fused-Filament Fabrication of Solid Dosage Forms
por: Fuenmayor, Evert, et al.
Publicado: (2018)

Genetic Interaction of tRNA-Dependent Mistranslation with Fused in Sarcoma Protein Aggregates
por: Lant, Jeremy T., et al.
Publicado: (2023)

Tau Protein Phosphorylated at Threonine-231 is Expressed Abundantly in the Cerebellum in Prion Encephalopathies
por: Gómez-López, Vıctor Manuel, et al.
Publicado: (2021)

From Prion Diseases to Prion-Like Propagation Mechanisms of Neurodegenerative Diseases
por: Acquatella-Tran Van Ba, Isabelle, et al.
Publicado: (2013)

Di‐ and Tetracyano‐Substituted Pyrene‐Fused Pyrazaacenes: Aggregation in the Solid State
por: Ueberricke, Lucas, et al.
Publicado: (2020)

The binding specificity of Translocated in LipoSarcoma/FUsed in Sarcoma with lncRNA transcribed from the promoter region of cyclin D1
por: Yoneda, Ryoma, et al.
Publicado: (2016)

Molecular Mechanisms in the Pathogenesis of Alzheimer’s disease and Tauopathies-Prion-Like Seeded Aggregation and Phosphorylation
por: Hasegawa, Masato
Publicado: (2016)

Enhanced phosphorylation of PERK in primary cultured neurons as an autonomous neuronal response to prion infection
por: Tanaka, Misaki, et al.
Publicado: (2020)

Effects of Solution Chemistry and Aging Time on Prion Protein Adsorption and Replication of Soil-Bound Prions
por: Saunders, Samuel E., et al.
Publicado: (2011)

Phosphorylation sites are evolutionary checkpoints against liquid–solid transition in protein condensates
por: Ranganathan, Srivastav, et al.
Publicado: (2023)

To FUSE(x) or not to FUSE(x) ...
por: Peters, Andreas Joachim
Publicado: (2020)

Clinical and Genetic Features of Patients with Juvenile Amyotrophic Lateral Sclerosis with Fused in Sarcoma (FUS) Mutation
por: Yu, Xiaolong, et al.
Publicado: (2018)

Extensive splicing changes in an ALS/FTD transgenic mouse model overexpressing cytoplasmic fused in sarcoma
por: Ito, Daisuke, et al.
Publicado: (2020)

Making of a single solid-state nanopore on the wall of fused silica capillary
por: Fang, Fang, et al.
Publicado: (2018)

Structures of Pathological and Functional Amyloids and Prions, a Solid-State NMR Perspective
por: Daskalov, Asen, et al.
Publicado: (2021)

Interaction of prion protein with acetylcholinesterase: potential pathobiological implications in prion diseases
por: Torrent, Joan, et al.
Publicado: (2015)

Development of a mouse monoclonal antibody for the detection of asymmetric dimethylarginine of Translocated in LipoSarcoma/FUsed in Sarcoma and its application in analyzing methylated TLS
por: Fujimoto, Kenta, et al.
Publicado: (2014)

Prions and Prion Diseases: Current Perspectives
por: Belay, Ermias D.
Publicado: (2004)

Classifying prion and prion-like phenomena
por: Harbi, Djamel, et al.
Publicado: (2014)

Silent Prions and Covert Prion Transmission
por: Mathiason, Candace K.
Publicado: (2015)

Expression of Fused in sarcoma mutations in mice recapitulates the neuropathology of FUS proteinopathies and provides insight into disease pathogenesis
por: Verbeeck, Christophe, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_vgnvuagq03phtfcafsm3l133mc