Cargando…

Shikonin promotes ubiquitination and degradation of cIAP1/2-mediated apoptosis and necrosis in triple negative breast cancer cells

BACKGROUND: Shikonin (SKO) is a natural naphthoquinone derived from Chinese herbal medicine Arnebiae Radix with high development potentials due to its anti-inflammatory and anti-tumor activities. Overwhelming evidences have indicated that SKO can induce both necrosis and apoptosis in cancer cells, w...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Anqi, Liu, Jiayu, Yang, Yuhan, Chen, Zhejie, Gao, Caifang, Wang, Zhanguo, Fu, Chaomei, Zou, Liang, Wang, Shengpeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7851907/ https://www.ncbi.nlm.nih.gov/pubmed/33526051 http://dx.doi.org/10.1186/s13020-021-00426-1

Ejemplares similares

LCL161 increases paclitaxel-induced apoptosis by degrading cIAP1 and cIAP2 in NSCLC
por: Yang, Chengcheng, et al.
Publicado: (2016)

Molecular determinants of Smac mimetic induced degradation of cIAP1 and cIAP2
por: Darding, M, et al.
Publicado: (2011)

Effects of cIAP-1, cIAP-2 and XIAP triple knockdown on prostate cancer cell susceptibility to apoptosis, cell survival and proliferation
por: Gill, Catherine, et al.
Publicado: (2009)

Cytoplasmic and Nuclear Functions of cIAP1
por: Zadoroznyj, Aymeric, et al.
Publicado: (2022)

Inhibitor of apoptosis proteins, NAIP, cIAP1 and cIAP2 expression during macrophage differentiation and M1/M2 polarization
por: Morón-Calvente, Virginia, et al.
Publicado: (2018)

HAX1 regulates E3 ubiquitin ligase activity of cIAPs by promoting their dimerization
por: Choi, Jin Sun, et al.
Publicado: (2014)

Structural insights into non-covalent ubiquitin activation of the cIAP1-UbcH5B∼ubiquitin complex
por: Patel, Amrita, et al.
Publicado: (2019)

Expression and Correlation of Cell-Free cIAP-1 and cIAP-2 mRNA in Breast Cancer Patients: A Study from India
por: Verma, Amit Kumar, et al.
Publicado: (2020)

cIAP1 regulates the EGFR/Snai2 axis in triple-negative breast cancer cells
por: Majorini, Maria Teresa, et al.
Publicado: (2018)

cIAP1 promotes proliferation and migration and prevents apoptosis in gallbladder cancer in vitro
por: Su, Wei, et al.
Publicado: (2019)

Rb inactivation accelerates neoplastic growth and substitutes for recurrent amplification of cIAP1, cIAP2 and Yap1 in sporadic mammary carcinoma associated with p53 deficiency
por: Cheng, Le, et al.
Publicado: (2010)

E2F1 binds to the peptide-binding groove within the BIR3 domain of cIAP1 and requires cIAP1 for chromatin binding
por: Allègre, Jennifer, et al.
Publicado: (2018)

Bivalent IAP antagonists, but not monovalent IAP antagonists, inhibit TNF-mediated NF-κB signaling by degrading TRAF2-associated cIAP1 in cancer cells
por: Mitsuuchi, Y, et al.
Publicado: (2017)

Activation of noncanonical NF-κB requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2, TRAF3 and the kinase NIK
por: Zarnegar, Brian J., et al.
Publicado: (2008)

TRIM56 promotes malignant progression of glioblastoma by stabilizing cIAP1 protein
por: Yang, Xu, et al.
Publicado: (2022)

cIAP-1 Controls Innate Immunity to C. pneumoniae Pulmonary Infection
por: Prakash, Hridayesh, et al.
Publicado: (2009)

cIAP1/2 are involved in the radiosensitizing effect of birinapant on NSCLC cell line in vitro
por: Sun, Hao, et al.
Publicado: (2021)

Correction: cIAP1 promotes proliferation and migration and prevents apoptosis in gallbladder cancer in vitro
Publicado: (2019)

ZFP36 stabilizes RIP1 via degradation of XIAP and cIAP2 thereby promoting ripoptosome assembly
por: Selmi, Tommaso, et al.
Publicado: (2015)

Role of A20 in cIAP-2 Protection against Tumor Necrosis Factor α (TNF-α)-Mediated Apoptosis in Endothelial Cells
por: Guo, Shuzhen, et al.
Publicado: (2014)

Bivalent IAP antagonists inhibit TRAF2-bound cIAPs and limit TNF-mediated NF-κB signaling
por: Condon, Stephen M
Publicado: (2016)

Ceramide targets xIAP and cIAP1 to sensitize metastatic colon and breast cancer cells to apoptosis induction to suppress tumor progression
por: Paschall, Amy V, et al.
Publicado: (2014)

Cellular Inhibitor of Apoptosis (cIAP)-Mediated Ubiquitination of Phosphofurin Acidic Cluster Sorting Protein 2 (PACS-2) Negatively Regulates Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) Cytotoxicity
por: Guicciardi, Maria Eugenia, et al.
Publicado: (2014)

Cellular inhibitor of apoptosis 2 (cIAP2) restricts neuroinflammation during experimental autoimmune encephalomyelitis
por: Biswas, Debolina D., et al.
Publicado: (2022)

TWEAK Promotes the Proliferation of Squamous Cell Carcinoma Cells Through Activating cIAP1 Signals
por: Liang, Lili, et al.
Publicado: (2020)

Close Relationship between cIAP2 and Human ARDS Induced by Severe H7N9 Infection
por: Qin, Chu, et al.
Publicado: (2019)

Scalp Acupuncture and Treadmill Training Inhibits Neuronal Apoptosis through Activating cIAP1 in Cerebral Ischemia Rats
por: Tang, Qiang, et al.
Publicado: (2021)

cIAP2 promotes gallbladder cancer invasion and lymphangiogenesis by activating the NF‐κB pathway
por: Jiang, Xiaojie, et al.
Publicado: (2017)

Anastasis enhances metastasis and chemoresistance of colorectal cancer cells through upregulating cIAP2/NFκB signaling
por: Wang, Ru, et al.
Publicado: (2023)

TAK1 kinase determines TRAIL sensitivity by modulating reactive oxygen species and cIAP
por: Morioka, Sho, et al.
Publicado: (2009)

PAR-4 overcomes chemo-resistance in breast cancer cells by antagonizing cIAP1
por: Guo, Haihong, et al.
Publicado: (2019)

USP11: A key regulator of cIAP2 stability and sensitivity to SMAC mimetics
por: Lee, Eun-Woo, et al.
Publicado: (2015)

RANKL enhances the effect of an antagonist of inhibitor of apoptosis proteins (cIAPs) in RANK-positive breast cancer cells
por: Casimiro, S., et al.
Publicado: (2013)

RETRACTED ARTICLE: Birinapant sensitizes platinum-resistant carcinomas with high levels of cIAP to carboplatin therapy
por: La, V., et al.
Publicado: (2017)

Retraction Note: Birinapant sensitizes platinum-resistant carcinomas with high levels of cIAP to carboplatin therapy
por: La, V., et al.
Publicado: (2021)

cIAPs control RIPK1 kinase activity‐dependent and ‐independent cell death and tissue inflammation
por: Schorn, Fabian, et al.
Publicado: (2023)

Targeted ablation of the cellular inhibitor of apoptosis 1 (cIAP1) attenuates denervation-induced skeletal muscle atrophy
por: Lala-Tabbert, Neena, et al.
Publicado: (2019)

A20 Promotes Ripoptosome Formation and TNF-Induced Apoptosis via cIAPs Regulation and NIK Stabilization in Keratinocytes
por: Feoktistova, Maria, et al.
Publicado: (2020)

shRNA Depletion of cIAP1 Sensitizes Human Ovarian Cancer Cells to Anticancer Agent-Induced Apoptosis
por: Jin, Hong, et al.
Publicado: (2015)

TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1–TRAF2 complex to sensitize tumor cells to TNFα
por: Vince, James E., et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_i0ln7mqigt6m7vbqgr4ungppjb