PP1 promotes cyclin B destruction and the metaphase–anaphase transition by dephosphorylating CDC20

Ubiquitin-dependent proteolysis of cyclin B and securin initiates sister chromatid segregation and anaphase. The anaphase-promoting complex/cyclosome and its coactivator CDC20 (APC/C(CDC20)) form the main ubiquitin E3 ligase for these two proteins. APC/C(CDC20) is regulated by CDK1-cyclin B and coun...

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Detalles Bibliográficos
Autores principales: Bancroft, James, Holder, James, Geraghty, Zoë, Alfonso-Pérez, Tatiana, Murphy, Daniel, Barr, Francis A., Gruneberg, Ulrike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7851957/
https://www.ncbi.nlm.nih.gov/pubmed/32755477
http://dx.doi.org/10.1091/mbc.E20-04-0252

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7851957/
https://www.ncbi.nlm.nih.gov/pubmed/32755477
http://dx.doi.org/10.1091/mbc.E20-04-0252

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