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Modeling mutational effects on biochemical phenotypes using convolutional neural networks: application to SARS-CoV-2

Biochemical phenotypes are major indexes for protein structure and function characterization. They are determined, at least in part, by the intrinsic physicochemical properties of amino acids and may be reflected in the protein three-dimensional structure. Modeling mutational effects on biochemical...

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Detalles Bibliográficos
Autores principales: Wang, Bo, Gamazon, Eric R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7852230/
https://www.ncbi.nlm.nih.gov/pubmed/33532766
http://dx.doi.org/10.1101/2021.01.28.428521