SARS-CoV-2 recruits a haem metabolite to evade antibody immunity

The coronaviral spike is the dominant viral antigen and the target of neutralizing antibodies. We show that SARS-CoV-2 spike binds biliverdin and bilirubin, the tetrapyrrole products of haem metabolism, with nanomolar affinity. Using cryo-electron microscopy and X-ray crystallography we mapped the t...

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Detalles Bibliográficos
Autores principales: Rosa, Annachiara, Pye, Valerie E., Graham, Carl, Muir, Luke, Seow, Jeffrey, Ng, Kevin W., Cook, Nicola J., Rees-Spear, Chloe, Parker, Eleanor, dos Santos, Mariana Silva, Rosadas, Carolina, Susana, Alberto, Rhys, Hefin, Nans, Andrea, Masino, Laura, Roustan, Chloe, Christodoulou, Evangelos, Ulferts, Rachel, Wrobel, Antoni, Short, Charlotte-Eve, Fertleman, Michael, Sanders, Rogier W., Heaney, Judith, Spyer, Moira, Kjær, Svend, Riddell, Andy, Malim, Michael H., Beale, Rupert, MacRae, James I., Taylor, Graham P., Nastouli, Eleni, van Gils, Marit J., Rosenthal, Peter B., Pizzato, Massimo, McClure, Myra O., Tedder, Richard S., Kassiotis, George, McCoy, Laura E., Doores, Katie J., Cherepanov, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7852234/
https://www.ncbi.nlm.nih.gov/pubmed/33532784
http://dx.doi.org/10.1101/2021.01.21.21249203

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7852234/
https://www.ncbi.nlm.nih.gov/pubmed/33532784
http://dx.doi.org/10.1101/2021.01.21.21249203

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