CD147 deficiency in T cells prevents thymic involution by inhibiting the EMT process in TECs in the presence of TGFβ

Thymic involution during aging is a major cause of decreased T-cell production and reduced immunity. Here, we show that the loss of CD147 on T cells prevents thymic senescence, resulting in slowed shrinkage of the thymus with age and increased production of naive T cells. This phenotype is the resul...

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Detalles Bibliográficos
Autores principales: Chen, Ruo, Wang, Ke, Feng, Zhuan, Zhang, Ming-Yang, Wu, Jiao, Geng, Jie-Jie, Chen, Zhi-Nan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7853129/
https://www.ncbi.nlm.nih.gov/pubmed/31900457
http://dx.doi.org/10.1038/s41423-019-0353-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7853129/
https://www.ncbi.nlm.nih.gov/pubmed/31900457
http://dx.doi.org/10.1038/s41423-019-0353-7

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