Cancer-Associated Gain-of-Function Mutations Activate a SWI/SNF-Family Regulatory Hub

SWI/SNF-family remodelers (BAF/PBAF in mammals) are essential chromatin regulators, and mutations in human BAF/PBAF components are associated with ∼20% of cancers. Cancer-associated missense mutations in human BRG1 (encoding the catalytic ATPase) have been characterized previously as conferring loss...

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Detalles Bibliográficos
Autores principales: Clapier, Cedric R., Verma, Naveen, Parnell, Timothy J., Cairns, Bradley R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7853424/
https://www.ncbi.nlm.nih.gov/pubmed/33058778
http://dx.doi.org/10.1016/j.molcel.2020.09.024

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7853424/
https://www.ncbi.nlm.nih.gov/pubmed/33058778
http://dx.doi.org/10.1016/j.molcel.2020.09.024

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