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Cancer-Associated Gain-of-Function Mutations Activate a SWI/SNF-Family Regulatory Hub
SWI/SNF-family remodelers (BAF/PBAF in mammals) are essential chromatin regulators, and mutations in human BAF/PBAF components are associated with ∼20% of cancers. Cancer-associated missense mutations in human BRG1 (encoding the catalytic ATPase) have been characterized previously as conferring loss...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cell Press
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7853424/ https://www.ncbi.nlm.nih.gov/pubmed/33058778 http://dx.doi.org/10.1016/j.molcel.2020.09.024 |