Phylogenomics of 8,839 Clostridioides difficile genomes reveals recombination-driven evolution and diversification of toxin A and B

Clostridioides difficile is the major worldwide cause of antibiotic-associated gastrointestinal infection. A pathogenicity locus (PaLoc) encoding one or two homologous toxins, toxin A (TcdA) and toxin B (TcdB), is essential for C. difficile pathogenicity. However, toxin sequence variation poses majo...

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Detalles Bibliográficos
Autores principales: Mansfield, Michael J., Tremblay, Benjamin J-M, Zeng, Ji, Wei, Xin, Hodgins, Harold, Worley, Jay, Bry, Lynn, Dong, Min, Doxey, Andrew C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7853461/
https://www.ncbi.nlm.nih.gov/pubmed/33370413
http://dx.doi.org/10.1371/journal.ppat.1009181

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7853461/
https://www.ncbi.nlm.nih.gov/pubmed/33370413
http://dx.doi.org/10.1371/journal.ppat.1009181

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