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Phylogenomics of 8,839 Clostridioides difficile genomes reveals recombination-driven evolution and diversification of toxin A and B
Clostridioides difficile is the major worldwide cause of antibiotic-associated gastrointestinal infection. A pathogenicity locus (PaLoc) encoding one or two homologous toxins, toxin A (TcdA) and toxin B (TcdB), is essential for C. difficile pathogenicity. However, toxin sequence variation poses majo...
Autores principales: | Mansfield, Michael J., Tremblay, Benjamin J-M, Zeng, Ji, Wei, Xin, Hodgins, Harold, Worley, Jay, Bry, Lynn, Dong, Min, Doxey, Andrew C. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7853461/ https://www.ncbi.nlm.nih.gov/pubmed/33370413 http://dx.doi.org/10.1371/journal.ppat.1009181 |
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