Iron derived from autophagy-mediated ferritin degradation induces cardiomyocyte death and heart failure in mice

Heart failure is a major public health problem, and abnormal iron metabolism is common in patients with heart failure. Although iron is necessary for metabolic homeostasis, it induces a programmed necrosis. Iron release from ferritin storage is through nuclear receptor coactivator 4 (NCOA4)-mediated...

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Detalles Bibliográficos
Autores principales: Ito, Jumpei, Omiya, Shigemiki, Rusu, Mara-Camelia, Ueda, Hiromichi, Murakawa, Tomokazu, Tanada, Yohei, Abe, Hajime, Nakahara, Kazuki, Asahi, Michio, Taneike, Manabu, Nishida, Kazuhiko, Shah, Ajay M, Otsu, Kinya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7853718/
https://www.ncbi.nlm.nih.gov/pubmed/33526170
http://dx.doi.org/10.7554/eLife.62174

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7853718/
https://www.ncbi.nlm.nih.gov/pubmed/33526170
http://dx.doi.org/10.7554/eLife.62174

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