Molecular mechanism for vitamin C-derived C(5)-glyceryl-methylcytosine DNA modification catalyzed by algal TET homologue CMD1

C(5)-glyceryl-methylcytosine (5gmC) is a novel DNA modification catalyzed by algal TET homologue CMD1 using vitamin C (VC) as co-substrate. Here, we report the structures of CMD1 in apo form and in complexes with VC or/and dsDNA. CMD1 exhibits comparable binding affinities for DNAs of different leng...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Wenjing, Zhang, Tianlong, Sun, Mingliang, Shi, Yu, Zhang, Xiao-Jie, Xu, Guo-Liang, Ding, Jianping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7854593/
https://www.ncbi.nlm.nih.gov/pubmed/33531488
http://dx.doi.org/10.1038/s41467-021-21061-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7854593/
https://www.ncbi.nlm.nih.gov/pubmed/33531488
http://dx.doi.org/10.1038/s41467-021-21061-2

Ejemplares similares