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Molecular mechanism for vitamin C-derived C(5)-glyceryl-methylcytosine DNA modification catalyzed by algal TET homologue CMD1

C(5)-glyceryl-methylcytosine (5gmC) is a novel DNA modification catalyzed by algal TET homologue CMD1 using vitamin C (VC) as co-substrate. Here, we report the structures of CMD1 in apo form and in complexes with VC or/and dsDNA. CMD1 exhibits comparable binding affinities for DNAs of different leng...

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Detalles Bibliográficos
Autores principales:	Li, Wenjing, Zhang, Tianlong, Sun, Mingliang, Shi, Yu, Zhang, Xiao-Jie, Xu, Guo-Liang, Ding, Jianping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7854593/ https://www.ncbi.nlm.nih.gov/pubmed/33531488 http://dx.doi.org/10.1038/s41467-021-21061-2

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