Anti-CfaE nanobodies provide broad cross-protection against major pathogenic enterotoxigenic Escherichia coli strains, with implications for vaccine design

Enterotoxigenic Escherichia coli (ETEC) is estimated to cause approximately 380,000 deaths annually during sporadic or epidemic outbreaks worldwide. Development of vaccines against ETEC is very challenging due to the vast heterogeneity of the ETEC strains. An effective vaccines would have to be mult...

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Detalles Bibliográficos
Autores principales: Amcheslavsky, Alla, Wallace, Aaron L., Ejemel, Monir, Li, Qi, McMahon, Conor T., Stoppato, Matteo, Giuntini, Serena, Schiller, Zachary A., Pondish, Jessica R., Toomey, Jacqueline R., Schneider, Ryan M., Meisinger, Jordan, Heukers, Raimond, Kruse, Andrew C., Barry, Eileen M., Pierce, Brian G., Klempner, Mark S., Cavacini, Lisa A., Wang, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7854682/
https://www.ncbi.nlm.nih.gov/pubmed/33531570
http://dx.doi.org/10.1038/s41598-021-81895-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7854682/
https://www.ncbi.nlm.nih.gov/pubmed/33531570
http://dx.doi.org/10.1038/s41598-021-81895-0

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