Histone Parylation factor 1 contributes to the inhibition of PARP1 by cancer drugs

Poly-(ADP-ribose) polymerase 1 and 2 (PARP1 and PARP2) are key enzymes in the DNA damage response. Four different inhibitors (PARPi) are currently in the clinic for treatment of ovarian and breast cancer. Recently, histone PARylation Factor 1 (HPF1) has been shown to play an essential role in the PA...

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Detalles Bibliográficos
Autores principales: Rudolph, Johannes, Roberts, Genevieve, Luger, Karolin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7854685/
https://www.ncbi.nlm.nih.gov/pubmed/33531508
http://dx.doi.org/10.1038/s41467-021-20998-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7854685/
https://www.ncbi.nlm.nih.gov/pubmed/33531508
http://dx.doi.org/10.1038/s41467-021-20998-8

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