A Proposed Concept for Defective Mitophagy Leading to Late Stage Ineffective Erythropoiesis in Pyruvate Kinase Deficiency

Pyruvate kinase deficiency (PKD) is a rare congenital hemolytic anemia caused by mutations in the PKLR gene. Here, we review pathophysiological aspects of PKD, focusing on the interplay between pyruvate kinase (PK)-activity and reticulocyte maturation in the light of ferroptosis, an iron-dependent p...

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Detalles Bibliográficos
Autores principales: van Vuren, Annelies Johanna, van Beers, Eduard Johannes, van Wijk, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7854701/
https://www.ncbi.nlm.nih.gov/pubmed/33551834
http://dx.doi.org/10.3389/fphys.2020.609103

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7854701/
https://www.ncbi.nlm.nih.gov/pubmed/33551834
http://dx.doi.org/10.3389/fphys.2020.609103

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