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Mechanotransduction via the coordinated actions of integrins, PI3K signaling and Connexin hemichannels
Mechanical loading opens connexin 43 (Cx43) hemichannels (HCs), leading to the release of bone anabolic molecules, such as prostaglandins, from mechanosensitive osteocytes, which is essential for bone formation and remodeling. However, the mechanotransduction mechanism that activates HCs remains elu...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7854719/ https://www.ncbi.nlm.nih.gov/pubmed/33531460 http://dx.doi.org/10.1038/s41413-020-00126-w |