CRISPR C-to-G base editors for inducing targeted DNA transversions in human cells

CRISPR-guided DNA cytosine and adenine base editors (CBEs and ABEs) are widely used for many applications(1–4) but primarily create DNA base transitions (i.e., pyrimidine-to-pyrimidine, or purine-to-purine). Here we describe the engineering of two base editor architectures that can efficiently induc...

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Detalles Bibliográficos
Autores principales: Kurt, Ibrahim C., Zhou, Ronghao, Iyer, Sowmya, Garcia, Sara P., Miller, Bret R., Langner, Lukas M., Grünewald, Julian, Joung, J. Keith
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7854778/
https://www.ncbi.nlm.nih.gov/pubmed/32690971
http://dx.doi.org/10.1038/s41587-020-0609-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7854778/
https://www.ncbi.nlm.nih.gov/pubmed/32690971
http://dx.doi.org/10.1038/s41587-020-0609-x

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