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CRISPR C-to-G base editors for inducing targeted DNA transversions in human cells
CRISPR-guided DNA cytosine and adenine base editors (CBEs and ABEs) are widely used for many applications(1–4) but primarily create DNA base transitions (i.e., pyrimidine-to-pyrimidine, or purine-to-purine). Here we describe the engineering of two base editor architectures that can efficiently induc...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7854778/ https://www.ncbi.nlm.nih.gov/pubmed/32690971 http://dx.doi.org/10.1038/s41587-020-0609-x |