Metformin effectively restores the HPA axis function in diet-induced obese rats

INTRODUCTION: The hypothalamo-pituitary-adrenal (HPA) axis is perturbed in obesity. We previously reported presence of leptin resistance in the brainstem and uncoupling between central noradrenergic tone and the HPA axis in obesity-prone (DIO) rats. Metformin is shown to lower body weight and adipos...

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Detalles Bibliográficos
Autores principales: Shin, Andrew C., Balasubramanian, Priya, Suryadevara, Pavan, Zyskowski, Justin, Herdt, Thomas H., MohanKumar, Sheba M. J., MohanKumar, Puliyur S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7855162/
https://www.ncbi.nlm.nih.gov/pubmed/32951009
http://dx.doi.org/10.1038/s41366-020-00688-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7855162/
https://www.ncbi.nlm.nih.gov/pubmed/32951009
http://dx.doi.org/10.1038/s41366-020-00688-z

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