Mechanism of Auto-inhibition and Activation of Mec1(ATR) Checkpoint Kinase

In response to DNA damage or replication fork stalling, the basal activity of Saccharomyces cerevisiae Mec1(ATR) is stimulated in a cell cycle dependent manner, leading to cell cycle arrest and promoting DNA repair. Mec1(ATR) dysfunction leads to cell death in yeast and causes chromosome instability...

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Detalles Bibliográficos
Autores principales: Tannous, Elias A., Yates, Luke A., Zhang, Xiaodong, Burgers, Peter M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7855233/
https://www.ncbi.nlm.nih.gov/pubmed/33169019
http://dx.doi.org/10.1038/s41594-020-00522-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7855233/
https://www.ncbi.nlm.nih.gov/pubmed/33169019
http://dx.doi.org/10.1038/s41594-020-00522-0

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