Cargando…

The Small Molecule BIBR1532 Exerts Potential Anti-cancer Activities in Preclinical Models of Feline Oral Squamous Cell Carcinoma Through Inhibition of Telomerase Activity and Down-Regulation of TERT

Expression of telomerase reverse transcriptase (TERT) and telomerase activity (TA) is a main feature of cancer, contributing to cell immortalization by causing telomeres dysfunction. BIBR1532 is a potent telomerase inhibitor that showed potential anti-tumor activities in several types of cancer, by...

Descripción completa

Detalles Bibliográficos
Autores principales: Altamura, Gennaro, degli Uberti, Barbara, Galiero, Giorgio, De Luca, Giovanna, Power, Karen, Licenziato, Luca, Maiolino, Paola, Borzacchiello, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7855307/
https://www.ncbi.nlm.nih.gov/pubmed/33553285
http://dx.doi.org/10.3389/fvets.2020.620776