NF-κB inducing kinase maintains T cell metabolic fitness in antitumor immunity

Metabolic reprograming towards aerobic glycolysis is a pivotal mechanism shaping immune responses. Here we show deficiency in NF-κB-inducing kinase (NIK) impairs glycolysis induction, rendering CD8(+) effector T cells hypofunctional in tumor microenvironment. Conversely, ectopic expression of NIK pr...

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Detalles Bibliográficos
Autores principales: Gu, Meidi, Zhou, Xiaofei, Sohn, Jee Hyung, Zhu, Lele, Jie, Zuliang, Yang, Jin-Young, Zheng, Xiaofeng, Xie, Xiaoping, Yang, Jie, Shi, Yaoyao, Brightbill, Hans D, Kim, Jae Bum, Wang, Jing, Cheng, Xuhong, Sun, Shao-Cong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7855506/
https://www.ncbi.nlm.nih.gov/pubmed/33398181
http://dx.doi.org/10.1038/s41590-020-00829-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7855506/
https://www.ncbi.nlm.nih.gov/pubmed/33398181
http://dx.doi.org/10.1038/s41590-020-00829-6

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