Smc3 dosage regulates B cell transit through germinal centers and restricts their malignant transformation

During the germinal center (GC) reaction, B cells undergo extensive redistribution of cohesin complex and 3D reorganization of their genomes. Yet, the significance of cohesin and architectural programming in the humoral immune response is unknown. Herein we report that homozygous deletion of Smc3 en...

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Detalles Bibliográficos
Autores principales: Rivas, Martín A., Meydan, Cem, Chin, Christopher R., Challman, Matt F., Kim, Daleum, Bhinder, Bhavneet, Kloetgen, Andreas, Viny, Aaron D., Teater, Matt R., McNally, Dylan R., Doane, Ashley S., Béguelin, Wendy, Fernández, María Teresa Calvo, Shen, Hao, Wang, Xiang, Levine, Ross L., Chen, Zhengming, Tsirigos, Aristotelis, Elemento, Olivier, Mason, Christopher E., Melnick, Ari M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7855695/
https://www.ncbi.nlm.nih.gov/pubmed/33432228
http://dx.doi.org/10.1038/s41590-020-00827-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7855695/
https://www.ncbi.nlm.nih.gov/pubmed/33432228
http://dx.doi.org/10.1038/s41590-020-00827-8

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