Rhophilin-2 Upregulates Glutamine Synthetase by Stabilizing c-Myc Protein and Confers Resistance to Glutamine Deprivation in Lung Cancer

INTRODUCTION: RHPN2, a member of rhophilin family of rho-binding proteins, regulates actin cytoskeleton and vesicular trafficking, and promotes mesenchymal transformation in cancer. We have found that RHPN2 was significantly mutated in lung adenocarcinoma (LUAD). However, the role of RHPN2 in lung c...

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Detalles Bibliográficos
Autores principales: Xiao, Dakai, He, Jiaxi, Guo, Zhihua, He, Huiming, Yang, Shengli, Huang, Liyan, Pan, Hui, He, Jianxing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7855701/
https://www.ncbi.nlm.nih.gov/pubmed/33552953
http://dx.doi.org/10.3389/fonc.2020.571384

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7855701/
https://www.ncbi.nlm.nih.gov/pubmed/33552953
http://dx.doi.org/10.3389/fonc.2020.571384

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