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PDE10A Inhibitors—Clinical Failure or Window Into Antipsychotic Drug Action?
PDE10A, a phosphodiesterase that inactivates both cAMP and cGMP, is a unique signaling molecule in being highly and nearly exclusively expressed in striatal medium spiny neurons. These neurons dynamically integrate cortical information with dopamine-signaled value to mediate action selection among a...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7855852/ https://www.ncbi.nlm.nih.gov/pubmed/33551724 http://dx.doi.org/10.3389/fnins.2020.600178 |