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A Neutralizing Antibody Targeting Oxidized Phospholipids Promotes Bone Anabolism in Chow‐Fed Young Adult Mice

Oxidized phospholipids containing phosphocholine (OxPL) are pro‐inflammatory lipid peroxidation products that bind to scavenger receptors (SRs), such as Scarb1, and toll‐like receptors (TLRs). Excessive OxPL, as found in oxidized low‐density lipoprotein (OxLDL), overwhelm these defense mechanisms an...

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Detalles Bibliográficos
Autores principales: Palmieri, Michela, Kim, Ha‐Neui, Gomez‐Acevedo, Horacio, Que, Xuchu, Tsimikas, Sotirios, Jilka, Robert L, Manolagas, Stavros C, Witztum, Joseph L, Ambrogini, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7855899/
https://www.ncbi.nlm.nih.gov/pubmed/32990984
http://dx.doi.org/10.1002/jbmr.4173