Cargando…

Nuclear partitioning of Prohibitin 1 inhibits Wnt/β-catenin-dependent intestinal tumorigenesis

The Wnt/β-catenin signaling pathway is aberrantly activated in the majority of colorectal cancer cases due to somatic mutations in the adenomatous polyposis coli (APC) gene. Prohibitin 1 (PHB1) serves pleiotropic cellular functions with dynamic subcellular trafficking facilitating signaling crosstal...

Descripción completa

Detalles Bibliográficos
Autores principales:	Alula, Kibrom M., Delgado-Deida, Yaritza, Jackson, Dakota N., Venuprasad, K., Theiss, Arianne L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7856018/ https://www.ncbi.nlm.nih.gov/pubmed/33144683 http://dx.doi.org/10.1038/s41388-020-01538-y

Ejemplares similares

The influence of mitochondrial-directed regulation of Wnt signaling on tumorigenesis
por: Delgado-Deida, Yaritza, et al.
Publicado: (2020)

Inner mitochondrial membrane protein Prohibitin 1 mediates Nix-induced, Parkin-independent mitophagy
por: Alula, Kibrom M., et al.
Publicado: (2023)

Autophagy in Crohn’s Disease: Converging on Dysfunctional Innate Immunity
por: Alula, Kibrom M., et al.
Publicado: (2023)

Mitochondrial dysfunction during loss of prohibitin 1 triggers Paneth cell defects and ileitis
por: Jackson, Dakota N, et al.
Publicado: (2020)

Targeting Mitochondrial Damage as a Therapeutic for Ileal Crohn’s Disease
por: Alula, Kibrom M., et al.
Publicado: (2021)

NLRP6 in host defense and intestinal inflammation
por: Venuprasad, K., et al.
Publicado: (2021)

Gut bacteria signaling to mitochondria in intestinal inflammation and cancer
por: Jackson, Dakota N., et al.
Publicado: (2019)

β-catenin tyrosine 654 phosphorylation increases Wnt signalling and intestinal tumorigenesis
por: van Veelen, Wendy, et al.
Publicado: (2011)

Prohibitin 1 Modulates Mitochondrial Stress-Related Autophagy in Human Colonic Epithelial Cells
por: Kathiria, Arwa S., et al.
Publicado: (2012)

β-catenin induces expression of prohibitin gene in acute leukemic cells
por: Kim, Dong Min, et al.
Publicado: (2017)

FAK/PYK2 promotes the Wnt/β-catenin pathway and intestinal tumorigenesis by phosphorylating GSK3β
por: Gao, Chenxi, et al.
Publicado: (2015)

Twa1/Gid8 is a β-catenin nuclear retention factor in Wnt signaling and colorectal tumorigenesis
por: Lu, Yi, et al.
Publicado: (2017)

Interplay of gut microbiota and host epithelial mitochondrial dysfunction is necessary for the development of spontaneous intestinal inflammation in mice
por: Alula, Kibrom M., et al.
Publicado: (2023)

A hypermorphic epithelial β-catenin mutation facilitates intestinal tumorigenesis in mice in response to compounding WNT-pathway mutations
por: Buchert, Michael, et al.
Publicado: (2015)

Significance of prohibitin domain family in tumorigenesis and its implication in cancer diagnosis and treatment
por: Yang, Jie, et al.
Publicado: (2018)

Farnesoid X receptor antagonizes Wnt/β-catenin signaling in colorectal tumorigenesis
por: Yu, Junhui, et al.
Publicado: (2020)

Slit2/Robo1 signaling promotes intestinal tumorigenesis through Src-mediated activation of the Wnt/β-catenin pathway
por: Zhang, Qian-Qian, et al.
Publicado: (2014)

SH3BP4 Regulates Intestinal Stem Cells and Tumorigenesis by Modulating β-Catenin Nuclear Localization
por: Antas, Pedro, et al.
Publicado: (2019)

Wnt/β-catenin signalling in ovarian cancer: Insights into its hyperactivation and function in tumorigenesis
por: Nguyen, Vu Hong Loan, et al.
Publicado: (2019)

Chromobox 4 facilitates tumorigenesis of lung adenocarcinoma through the Wnt/β-catenin pathway
por: Wang, Zuoyun, et al.
Publicado: (2020)

β-Catenin mutations and aberrant nuclear expression during endometrial tumorigenesis
por: Saegusa, M, et al.
Publicado: (2001)

Elevated d-2-hydroxyglutarate during colitis drives progression to colorectal cancer
por: Han, Jie, et al.
Publicado: (2018)

PRC1 contributes to tumorigenesis of lung adenocarcinoma in association with the Wnt/β-catenin signaling pathway
por: Zhan, Ping, et al.
Publicado: (2017)

TIEG1 modulates β-catenin sub-cellular localization and enhances Wnt signaling in bone
por: Subramaniam, Malayannan, et al.
Publicado: (2017)

β-catenin in epithelial tumorigenesis
por: Lu, Tsai-Ling, et al.
Publicado: (2015)

Complex interplay between β-catenin signalling and Notch effectors in intestinal tumorigenesis
por: Peignon, Grégory, et al.
Publicado: (2011)

Prohibitin-1 Transgenic Mice Revealed an Important Role of Prohibitin in Testicular Steroidogenesis
por: Bassi, Geetika, et al.
Publicado: (2021)

Nuclear localization is required for Dishevelled function in Wnt/β-catenin signaling
por: Itoh, Keiji, et al.
Publicado: (2005)

RBM5 inhibits tumorigenesis of gliomas through inhibition of Wnt/β-catenin signaling and induction of apoptosis
por: Jiang, Yuanpei, et al.
Publicado: (2017)

TIPE2 suppresses progression and tumorigenesis of esophageal carcinoma via inhibition of the Wnt/β-catenin pathway
por: Zhu, Linan, et al.
Publicado: (2018)

Cell–cell adhesion: linking Wnt/β-catenin signaling with partial EMT and stemness traits in tumorigenesis
por: Basu, Sayon, et al.
Publicado: (2018)

circ_0003418 Inhibits Tumorigenesis And Cisplatin Chemoresistance Through Wnt/β-Catenin Pathway In Hepatocellular Carcinoma
por: Chen, Hang, et al.
Publicado: (2019)

ANDROGEN RECEPTOR WITH SHORT POLYGLUTAMINE TRACT PREFERABLY ENHANCES WNT/β-CATENIN MEDIATED PROSTATIC TUMORIGENESIS
por: He, Yongfeng, et al.
Publicado: (2020)

Curcumin suppresses colorectal tumorigenesis via the Wnt/β-catenin signaling pathway by downregulating Axin2
por: Hao, Jiaxue, et al.
Publicado: (2021)

ZNRF3 Inhibits the Invasion and Tumorigenesis in Nasopharyngeal Carcinoma Cells by Inactivating the Wnt/β-Catenin Pathway
por: Wang, Zhongwei, et al.
Publicado: (2017)

IRF3 prevents colorectal tumorigenesis via inhibiting the nuclear translocation of β-catenin
por: Tian, Miao, et al.
Publicado: (2020)

Induction of Paclitaxel Resistance by ERα Mediated Prohibitin Mitochondrial-Nuclear Shuttling
por: Dong, Pei, et al.
Publicado: (2013)

Sphingosine-1-phosphate: Driver of NFκB and STAT3 persistent activation in chronic intestinal inflammation and colitis-associated cancer
por: Theiss, Arianne L
Publicado: (2013)

Pak2-mediated phosphorylation promotes RORγt ubiquitination and inhibits colonic inflammation
por: Kathania, Mahesh, et al.
Publicado: (2022)

Naked1 Antagonizes Wnt Signaling by Preventing Nuclear Accumulation of β-Catenin
por: Van Raay, Terence J., et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_6eo7k5s0gcaao4g8v4rh0tertr