Systematic review and meta-analysis of human transcriptomics reveals neuroinflammation, deficient energy metabolism, and proteostasis failure across neurodegeneration

Neurodegenerative disorders such as Alzheimer’s disease (AD), Lewy body diseases (LBD), and the amyotrophic lateral sclerosis and frontotemporal dementia (ALS-FTD) spectrum are defined by the accumulation of specific misfolded protein aggregates. However, the mechanisms by which each proteinopathy l...

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Detalles Bibliográficos
Autores principales: Noori, Ayush, Mezlini, Aziz M., Hyman, Bradley T., Serrano-Pozo, Alberto, Das, Sudeshna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7856076/
https://www.ncbi.nlm.nih.gov/pubmed/33347974
http://dx.doi.org/10.1016/j.nbd.2020.105225

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7856076/
https://www.ncbi.nlm.nih.gov/pubmed/33347974
http://dx.doi.org/10.1016/j.nbd.2020.105225

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