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Optimal two-stage designs based on restricted mean survival time for a single-arm study
Restricted mean survival time is an alternative measure of treatment effect to hazard ratio in clinical trials with time-to-event outcome. The current methods have been focused on one-stage designs. In this article, we propose optimal two-stage designs for a single-arm study with the smallest expect...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Elsevier
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7856426/ https://www.ncbi.nlm.nih.gov/pubmed/33553801 http://dx.doi.org/10.1016/j.conctc.2021.100732 |